pI: 5.757 |
Length (AA): 602 |
MW (Da): 69015 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 389 | 4ozu (A) | 6 | 392 | 43.00 | 0 | 1 | 1.23836 | -0.92 |
4 | 396 | 2aq5 (A) | 8 | 401 | 24.00 | 0 | 1 | 0.948324 | -0.12 |
69 | 164 | 3ewe (A) | 207 | 344 | 39.00 | 0.45 | 0.81 | 0.420068 | 0.21 |
70 | 155 | 4aow (A) | 11 | 92 | 27.00 | 0.039 | 0.21 | 0.431457 | -0.47 |
73 | 169 | 4yvd (A) | 287 | 373 | 29.00 | 0.047 | 0.59 | 0.42573 | -0.35 |
86 | 271 | 4ycz (A) | 29 | 218 | 30.00 | 0.001 | 0.94 | 0.51057 | 0.53 |
453 | 599 | 4uos (A) | 3 | 148 | 11.00 | 0.011 | 0.01 | 0.443686 | -1.15 |
464 | 561 | 3u59 (A) | 1 | 98 | 14.00 | 0.98 | 0 | 0.372291 | -0.96 |
506 | 602 | 2e7s (A) | 31 | 129 | 13.00 | 0.83 | 0 | 0.30963 | -0.65 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early schizont, late schizont, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, early ring, Ring, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, gametocyte, late ring, late trophozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Oocyst, Female Gametocyte. | Zanghi G Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_126943)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III008710 | WD domain, G-beta repeat containing protein |
Brugia malayi | Bm1_44715 | Coronin-like protein |
Candida albicans | CaO19.6535 | coronin, actin-binding protein |
Candida albicans | CaO19.13888 | coronin, actin-binding protein |
Candida albicans | CaO19_6535 | hypothetical protein |
Caenorhabditis elegans | CELE_R01H10.3 | Protein COR-1, isoform C |
Cryptosporidium hominis | Chro.70487 | coronin |
Cryptosporidium parvum | cgd7_4400 | coronin-type WD40 protein |
Dictyostelium discoideum | DDB_G0267382 | WD-40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG9446 | CG9446 gene product from transcript CG9446-RA |
Echinococcus granulosus | EgrG_000294400 | coronin actin binding protein 1C |
Echinococcus granulosus | EgrG_000258300 | coronin 1C |
Echinococcus granulosus | EgrG_001056750 | WD40 repeat subgroup |
Entamoeba histolytica | EHI_083590 | coronin, putative |
Entamoeba histolytica | EHI_105330 | coronin, putative |
Echinococcus multilocularis | EmuJ_001056750 | WD40 repeat, subgroup |
Echinococcus multilocularis | EmuJ_000294400 | coronin, actin binding protein, 1C |
Echinococcus multilocularis | EmuJ_000258300 | coronin 1C |
Homo sapiens | ENSG00000102879 | coronin, actin binding protein, 1A |
Homo sapiens | ENSG00000110880 | coronin, actin binding protein, 1C |
Homo sapiens | ENSG00000172725 | coronin, actin binding protein, 1B |
Homo sapiens | ENSG00000103647 | coronin, actin binding protein, 2B |
Homo sapiens | ENSG00000167549 | coronin 6 |
Homo sapiens | ENSG00000106789 | coronin, actin binding protein, 2A |
Leishmania braziliensis | LbrM.23.1260 | coronin, putative |
Leishmania donovani | LdBPK_231400.1 | coronin, putative |
Leishmania infantum | LinJ.23.1400 | coronin |
Leishmania major | LmjF.23.1165 | coronin, putative |
Leishmania mexicana | LmxM.23.1165 | coronin, putative |
Loa Loa (eye worm) | LOAG_05172 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08004 | hypothetical protein |
Mus musculus | ENSMUSG00000024835 | coronin, actin binding protein 1B |
Mus musculus | ENSMUSG00000041729 | coronin, actin binding protein, 2B |
Mus musculus | ENSMUSG00000030707 | coronin, actin binding protein 1A |
Mus musculus | ENSMUSG00000028337 | coronin, actin binding protein 2A |
Mus musculus | ENSMUSG00000004530 | coronin, actin binding protein 1C |
Mus musculus | ENSMUSG00000020836 | coronin 6 |
Neospora caninum | NCLIV_059340 | hypothetical protein, conserved |
Plasmodium berghei | PBANKA_1464100 | coronin |
Plasmodium falciparum | PF3D7_1251200 | coronin |
Plasmodium knowlesi | PKNH_1471200 | coronin, putative |
Plasmodium vivax | PVX_101450 | coronin, putative |
Plasmodium yoelii | PY01337 | Coronin |
Saccharomyces cerevisiae | YLR429W | Crn1p |
Schistosoma japonicum | Sjp_0113860 | expressed protein |
Schistosoma japonicum | Sjp_0022510 | Coronin-1B, putative |
Schistosoma mansoni | Smp_012720 | coronin |
Schmidtea mediterranea | mk4.000079.05 | Coronin-like protein cor-1 |
Schmidtea mediterranea | mk4.000017.22 | Coronin-like protein cor-1 |
Schmidtea mediterranea | mk4.000296.05 | Coronin-like protein cor-1 |
Trypanosoma brucei gambiense | Tbg972.8.2810 | coronin, putative |
Trypanosoma brucei | Tb927.8.3100 | coronin, putative |
Trypanosoma cruzi | TcCLB.510515.100 | coronin, putative |
Trypanosoma cruzi | TcCLB.509859.80 | coronin, putative |
Toxoplasma gondii | TGME49_216970 | coronin, putative |
Theileria parva | TP04_0772 | coronin, putative |
Trichomonas vaginalis | TVAG_177180 | WD-repeat protein, putative |
Trichomonas vaginalis | TVAG_222320 | WD-repeat protein, putative |
Trichomonas vaginalis | TVAG_124870 | WD-repeat protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3100 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.3100 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_216970 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.